Purpose(s)
Many risk factors of cancer have been established, but the contribution of paternal age in this regard remains largely unexplored. To further understand the etiology of cancer, we investigated the relationship between paternal age and cancer incidence using PLCO cohort.
Method(s)
The PLCO cancer screening trial designed to assess the effect of screening methods on the mortality of prostate, lung, colorectal and ovarian cancers. The trial began with about 155,000 men and women aged between 55 and 74 from 10 screening centers in the United States.
Cox proportional hazards regression analysis was performed to calculate hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) to assess the relationship between paternal age and risk of cancer.
Result(s)
Paternal age was associated with a lower hazard rate for cancers of the respiratory .
paternal age is significantly associated with reduced risk of cancers of the female genitalia.
A similar association of advanced paternal age and the risk of lung cancer was observed.
Conclusion(s)
In this cohort study, we found a significant association of advanced paternal age with reduced risk of cancers of the female genitalia, cancers of the respiratory and intrathoracic organs (including lung cancer) among individuals of 55 years and above in the PLCO Cancer Screening Trial.