CHUN-XIA ZHANG
China Pharmaceutical University
School of Science
High-selectivity SIM of the In-source Fragmentation Sapogenin Product Ions in Positive Mode Delineates the Holistic Profiles of Ginsenoside: A Novel Characteristic Chromatogram Facilitating the Simultaneous Identification of Seven Herbal Medicines Derived from the Panax Genus
Purpose(s)
Unveil the genesic mechanism and explore its potential significance in quality control of Ginseng and the related compound formulae
Method(s)
A novel characteristic chromatogram: selective ion monitoring (SIM) of in-source CID fragments
Result(s)
Chemometric analysis, based on the CC data of seven Ginseng drugs ( P. ginseng, P. quinquefolius, P. notoginseng , Red ginseng, leaf of P. ginseng, P. japonicus , and P. japonicus var. major ), disclosed 35 marker compounds.
Discriminate among P. ginseng, P. quinquefolius , and P. notoginseng , in 15 different compound formulae by identifying these marker compounds on both the Vion IMS-QTOF and QTrap 4500 mass spectrome-ters.
Conclusion(s)
The simultaneous identification and differentiation of seven Ginseng drugs can be achieved by a single IM-SIM CC method, ensuring the good applicability